Endocrine Abstracts

Objective: To develop and validate the adult hypopituitarism questionnaire (AHQ) as a disease-specific, self-administered questionnaire for evaluation of QOL in adult patients with hypopituitarism.Methods: The development and validation of a new questionnaire were performed in a standardized manner: item development, pilot-testing and psychometric validation.Result: Content validity of the initial questionnaire was evaluated via tw...

Introduction: Brugade syndrome (BS) is a cardiac disorder characterized by typical electrocardiograph (ECG) alterations and is known to have a high risk of sudden cardiac death (SCD). Isolated ACTH deficiency (IAD) is often associated with fetal arrhythmia. Previous reports have suggested that certain endocrine diseases might cause Brugada-like ECG forms. We present a case of IAD with BS who died suddenly.Case presentation: Forty-one year-old man was ref...

While the importance of fibroblast growth factor 23 (FGF-23) is established in the pathogenesis of phosphate wasting disorders, little is known about the mechanisms regulating its circulating level. To investigate the role of parathyroid hormone (PTH) in FGF-23 homeostasis, cinacalcet hydrochloride, a calcimimetic compound to suppress PTH secretion, was administered to the patients with primary hyperparathyroidism (PHPT). Fourteen patients with PHPT, who met the guidelines of ...